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KMID : 0370220120560040211
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Yakhak Hoeji
2012 Volume.56 No. 4 p.211 ~ p.216
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Development of Dissolution Test Method for Buflomedil Hydrochloride Tablets and Ticlopidine Hydrochloride Tablets
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Lee Ryun-Kyung
Jeong Gyeong-Rok
Oh Hyun-Sook
Shim Jee-Youn
Suh Sang-Chul
Lee Hyo-Jung
Kim Min-A
Park Seong-Min
Lee Kyu-Ha
Sohn Kyung-Hee
Kim In-Kyu
Sah Hong-Kee
Choi Hoo-Kyun
Cho Tae-Yong
Hong Choong-Man
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Abstract
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Drug dissolution test has been used for the purpose of both quality control of solid oral dosage forms and predicting in vivo drug release profiles. In this study, the dissolution profiles of buflomedil hydrochloride tablets and ticlopidine hydrochloride tablets were investigated according to the “Guidelines on Specifications of Dissolution tests for Oral dosage forms” of Korean Pharmacopoeia (KP). The analytical method using HPLC was validated. The validation was performed in terms of specificity, linearity, accuracy, precision and limit of quantitation.
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KEYWORD
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dissolution test, buflomedil - HCl, ticlopidine - HCl
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